Search results for " Wave"
Article
Validation of the production of influenza virus in ReadyToProcess WAVE™ 25 bioreactor system
A 2 L process, developed using the predecessor WAVE Biorector™ 20/50 system, was used as a starting point. Compared with WAVE Biorector™ 20/50, the successor ReadyToProcess WAVE 25 system allows using…
Article
Bracing for a Future Wave of Advanced Therapies
Buoyed by the regulatory approval of several cell and gene therapy (CGT) products for difficult-to-treat diseases, the US biopharma industry is now bracing for a new wave of CGTs in the near future as…
Article
ReadyToProcess WAVE 25 Bioreactor System
With ReadyToProcess WAVE 25, the rocking technology is enhanced with features such as advanced sensors and intelligent control strategies. System operation is easily managed via the intuitive and user…
Article
Process Development and Optimization Using the ReadyToProcess WAVE™ 25 Bioreactor System in Dual Mode
Download this application note to learn about the technical feasibility of the Method editor and operations in dual mode (where two parallel cultures are controlled independently) are demonstrated. …
Poster
Validation of the Production of Influenza Virus
A 2 L process, developed using the predecessor WAVE Bioreactor™ 20/50 system, was used as a starting point. Compared with WAVE Bioreactor 20/50, the successor ReadyToProcess WAVE 25 system allows usin…
Poster
Validation of Cytodex™ Gamma microcarrier-based virus production in single-use bioreactor systems
Here, we describe different approaches for the cultivation of Vero cells using Cytodex and Cytodex Gamma microcarriers in serum-free cultivation medium using spinners, WAVE Bioreactor™ 20/50, ReadyToP…
Article
A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAbs at Large Scale
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We have developed a reliable small-scale model for a monoclonal antibody (mAb) perfusion process using TPP® TubeSpin® Bioreactor tubes and the ReadyToProcess WAVE 25 R…
Article
Scalable ADCF Virus Production Using HyClone™ VaccineXpress Medium
The results were used for scaling up the process to a ReadyToProcess WAVE 25 bioreactor system at a 2-L working volume. The data show that the ADCF process using VaccineXpress for rotavirus propagatio…
Article
Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
The cells in the 10 L cultures were grown on Cytodex 1 microcarriers (3 g/L) in the WAVE Bioreactor 20/50 system. The cells were grown to a cell concentration of approximately 3 × 106 cells/mL. The ce…
Article
A Small-Scale Model to Increase Yield in Cell Culture Perfusion of mAb at Large Scale
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As process intensification is adopted into large-scale manufacturing, the responsibility on scale-down models to accurately represent the expanded operating space quickly follow…